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Papers of the Week

Papers: 13 Jul 2019 - 19 Jul 2019

Human Studies

2019 Jul 09

BMJ Open



Randomised controlled trial to investigate the effectiveness of thoracic epidural and paravertebral blockade in reducing chronic post-thoracotomy pain (TOPIC): a pilot study to assess feasibility of a large multicentre trial.


Yeung J, Middleton L, Tryposkiadis K, Kerr A, Daniels J, Naidu B, Melody T, Goebel A, Wilson M, Kumar S, Szentgyorgyi L, Flanagan S, Shah R, Worrall A, Gao F
BMJ Open. 2019 Jul 09; 9(7):e023679.
PMID: 31292172.


Thoracotomy is considered one of the most painful surgical procedures. The incidence of chronic post-thoracotomy pain (CPTP) is up to 50%. Paravertebral blockade (PVB) may be superior to thoracic epidural blockade (TEB) in preventing CPTP. The specific objective of this pilot study was to assess the feasibility of conducting a larger trial to determine whether PVB at thoracotomy is more effective in reducing CPTP compared with TEB.