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Papers of the Week

2019 Oct

J Pharm Pharmacol



Cannabinoid receptors in osteoporosis and osteoporotic pain: a narrative update of review.


Wang J, Lu H-X, Wang J
J Pharm Pharmacol. 2019 Oct; 71(10):1469-1474.
PMID: 31294469.


Osteoporosis is a skeletal disease with decreased bone mass and alteration in microarchitecture of bone tissue, and these changes put patients in risk of bone fracture. As a common symptom of osteoporosis and complication of osteoporotic fracture, chronic pain is a headache for clinicians. Nonsteroidal anti-inflammatory drugs (NSAIDs), selective COX-2 inhibitors and opioid drugs can temporarily reduce osteoporotic pain but have relevant side effects, such as addiction, tolerability and safety. The review summarized the recent advancements in the study of CB receptors in osteoporosis and osteoporotic pain and related mechanisms.