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Papers of the Week

2019 Aug

Am J Gastroenterol



Prucalopride in Gastroparesis: A Randomized Placebo-Controlled Crossover Study.


Carbone F, Van den Houte K, Clevers E, Andrews CN, Papathanasopoulos A, Holvoet L, van Oudenhove L, Caenepeel P, Arts J, Vanuytsel T, Tack J
Am J Gastroenterol. 2019 Aug; 114(8):1265-1274.
PMID: 31295161.


Prokinetics are considered the preferred treatment option for gastroparesis, but evidence of their efficacy is scarce. Prucalopride, a selective 5-hydroxytryptamine 4 receptor agonist used in the treatment of constipation, is able to enhance the gastric emptying rate. In a double-blind, randomized, placebo-controlled crossover study, we evaluated the efficacy of prucalopride to improve the gastric emptying rate and symptoms in patients with gastroparesis.