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PLoS One



Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA; an exploratory study.


van Helvoort EM, Popov-Celeketic J, Eijkelkamp N, Coeleveld K, Tryfonidou MA, Wijne CD, Hack CE, Lafeber FPJG, Mastbergen SC
PLoS One. 2019; 14(7):e0219587.
PMID: 31295306.


An ideal disease modifying osteoarthritis drug (DMOAD) has chondroprotective, anti-inflammatory, and analgesic effects. This study describes the production and characterization of a canine IL4-10 fusion protein (IL4-10 FP) and evaluates its in vivo DMOAD activity in a canine model of osteoarthritis (OA).