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Papers of the Week

Papers: 13 Jul 2019 - 19 Jul 2019

Animal Studies

2019 Sep 03

Biochem Biophys Res Commun



Spinal miR-34a regulates inflammatory pain by targeting SIRT1 in complete Freund’s adjuvant mice.


Chen S, Gu Y, Dai Q, He Y, Wang J
Biochem Biophys Res Commun. 2019 Sep 03; 516(4):1196-1203.
PMID: 31296380.


Sirtuin1 (SIRT1), which is regulated by microRNA-34a (miR-34a), can modulate pathophysiology processes, including nonalcoholic fatty liver disease and intestinal ischemia/reperfusion injury. We previously reported that SIRT1, an NAD-dependent deacetylase, plays a vital role in the development of neuropathic pain. However, the role of miR-34a/SIRT1 in complete Freund's adjuvant (CFA)-induced inflammatory pain remains unclear. In the present study, we examined miR-34a and SIRT1 in CFA mice. MiR-34a levels increased, while SIRT1 decreased in the spinal cord. Inhibiting miR-34a by intrathecal injection of miR-34a antagomir attenuated CFA-induced pain behavior. Moreover, miR-34a antagomir inhibited the CFA-induced SIRT1 decrease in the spinal cord. Furthermore, the analgesic effect of miR-34a antagomir was abrogated by the SIRT1 inhibitor EX-527. Our data provide support that the underlying mechanisms of miR-34a in promoting inflammatory pain may involve negative regulation of SIRT1.