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Papers of the Week

2019 Jul

Eur Rev Med Pharmacol Sci



Bradykinin alleviates DR retinal endothelial injury by regulating HMGB-1/NF-κB pathway.


Zhu Y, Li X-Y, Wang J, Zhu Y-G
Eur Rev Med Pharmacol Sci. 2019 Jul; 23(13):5535-5541.
PMID: 31298304.


Diabetic retinopathy (DR) is one of the most important complications of diabetes (DM) and the leading cause of blindness in adults. Bradykinin (BK) is involved in several pathophysiological processes, such as inflammation, pain, cell proliferation, and tumors. It plays a crucial role in corneal epithelial cells, corneal stromal cells, and fibroblasts. However, the role of BK in DR retinal endothelial injury remains unclear.