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Papers of the Week


Papers: 18 Jan 2025 - 24 Jan 2025


2025 Jan 17


Life Sci


39828229

(-) – (11R, 12S)-mefloquine ameliorates neuropathic pain by modulating Cx36-ER stress interaction in the pain-related central nervous system in rats.

Authors

Gu L, Lai Z, Zhang C, Liu Z, Huo Y, Qian Y, Wang B, Wang Z, Zhao Z, Hu W, Ma M

Abstract

To explore the specific molecular and cellular mechanisms of (-) – Mefloquine (one of Mefloquine’s enantiomers) in modulating the interaction between Connexin 36 (Cx36) and endoplasmic reticulum stress (ERS) both in rats with CCI-induced neuropathic pain and in tunicamycin-induced ERS cells.