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Papers: 6 Jul 2019 - 12 Jul 2019
Human Studies, Pharmacology/Drug Development
PAIN TYPE:
Migraine/Headache
2019 Dec
Cephalalgia
39
14
Migraine is associated with activation of the trigeminovascular system, release of calcitonin gene-related peptide (CGRP) and dilation of dural arteries. Novel treatments target calcitonin gene-related peptide or its receptor, which are present in all vascular beds, raising cardiovascular concerns. Erenumab is a human CGRP-receptor antibody approved for the prophylactic treatment of migraine.