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Papers of the Week

2019 Oct

Acta Anaesthesiol Scand



Intraoperative methadone for postoperative pain after laparoscopic hysterectomy: Protocol for a randomised, double-blind trial.


Friesgaard KD, Brix LD, Kristensen CB, Rian O, Nikolajsen L
Acta Anaesthesiol Scand. 2019 Oct; 63(9):1257-1261.
PMID: 31276190.


Hysterectomy is often carried out as same-day surgery. Treatment of postoperative pain is therefore of utmost importance to ensure timely discharge from hospital. Methadone has several desirable pharmacological features, including a long elimination half-life. Theoretically, a single intraoperative dose could provide long-lasting pain relief.