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Papers of the Week

Papers: 6 Jul 2019 - 12 Jul 2019

Human Studies


PLoS One



Differences in the miRNA signatures of chronic musculoskeletal pain patients from neuropathic or nociceptive origins.


Dayer C F, Luthi F, Le Carré J, Vuistiner P, Terrier P, Benaim C, Giacobino J-P, Léger B
PLoS One. 2019; 14(7):e0219311.
PMID: 31276478.


The quality of life for millions of people worldwide is affected by chronic pain. In addition to the effect of chronic pain on well-being, chronic pain has also been associated with poor health conditions and increased mortality. Due to its multifactorial origin, the classification of pain types remains challenging. MicroRNAs (miRNA) are small molecules that regulate gene expression. They are released into the bloodstream in a stable manner under normal and pathological conditions and have been described as potential biomarkers. In the present study, we aimed to investigate whether pain may induce an aberrant, specific dysregulation of miRNA expression, depending on the origin of the pain.