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Papers of the Week

Papers: 29 Jun 2019 - 5 Jul 2019

Human Studies

2019 Nov

Pain Pract



Genetic contribution in low back pain: a prospective genetic association study.


Margarit C, Roca R, Inda M-D-M, Muriel J, Ballester P, Moreu R, Conte A L, Nuñez A, Morales D, Peiró A
Pain Pract. 2019 Nov; 19(8):836-847.
PMID: 31269327.


Chronic pain is one of the commonest reasons individuals seek medical attention. It is a major issue because of the wide inter-individual variability in the analgesic response. This might be partly explained by the presence of variants in genes encoding molecules involved in pharmacodynamics and pharmacokinetics. The aim was to analyze opioid effectiveness in chronic low-back pain (CLBP) relief after opioid titration, unveiling the impact of pharmacogenetics.