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Papers of the Week
In silico validation of non-antibiotic drugs, acetaminophen and ibuprofen as antibacterial agents against red complex pathogens.
Abstract
Acetaminophen and ibuprofen are drugs commonly used to alleviate pain due to their anti-inflammatory, anti-pyretic and analgesic effect. The aim of the present study is to unravel the molecular mechanisms underlying the antimicrobial potential of these two drugs against red complex pathogens viz., Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, by employing in silico tools, since they are potentially associated with inflammatory conditions related to periodontal infections.