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Papers of the Week


2019 Jul 01


Korean J Pain


32


3

The antinociceptive effect of artemisinin on the inflammatory pain and role of GABAergic and opioidergic systems.

Authors

Mahdian Dehkordi F, Kaboutari J, Zendehdel M, Javdani M
Korean J Pain. 2019 Jul 01; 32(3):160-167.
PMID: 31257824.

Abstract

Pain is a complex mechanism which involves different systems, including the opioidergic and GABAergic systems. Due to the side effects of chemical analgesic agents, attention toward natural agents have been increased. Artemisinin is an herbal compound with widespread modern and traditional therapeutic indications, which its interaction with the GABAergic system and antinoniceptive effects on neuropathic pain have shown. Therefore, this study was designed to evaluate the antinociceptive effects of artemisinin during inflammatory pain and interaction with the GABAergic and opioidergic systems by using a writhing response test.