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Papers of the Week

2019 Jul 01

Korean J Pain



Diverse characters of Brennan’s paw incision model regarding certain parameters in the rat.


Kumar R, Gupta S, Gautam M, Kaler Jhajhria S, Ray S B
Korean J Pain. 2019 Jul 01; 32(3):168-177.
PMID: 31257825.


Brennan's rodent paw incision model has been extensively used for understanding mechanisms underlying postoperative pain in humans. However, alterations of physiological parameters like blood pressure and heart rate, or even feeding and drinking patterns after the incision have not been documented as yet. Moreover, though eicosanoids like prostaglandins and leukotrienes contribute to inflammation, tissue levels of these inflammatory mediators have never been studied. This work further investigates the antinociceptive effect of protein C after intra-wound administration.