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Papers of the Week

Papers: 29 Jun 2019 - 5 Jul 2019

Animal Studies


2019 Dec




Basal astrocyte and microglia activation in the central nervous system of Familial Hemiplegic Migraine Type I mice.


Magni G, Boccazzi M, Bodini A, Abbracchio MP, van den Maagdenberg AMJM, Ceruti S
Cephalalgia. 2019 Dec; 39(14):1809-1817.
PMID: 31260335.


Gain-of-function missense mutations in the α subunit of neuronal Ca2.1 channels, which define Familial Hemiplegic Migraine Type 1 (FHM1), result in enhanced cortical glutamatergic transmission and a higher susceptibility to cortical spreading depolarization. It is now well established that neurons signal to surrounding glial cells, namely astrocytes and microglia, in the central nervous system, which in turn become activated and in pathological conditions can sustain neuroinflammation. We and others previously demonstrated an increased activation of pro-algogenic pathways, paralleled by augmented macrophage infiltration, in both isolated trigeminal ganglia and mixed trigeminal ganglion neuron-satellite glial cell cultures of FHM1 mutant mice. Hence, we hypothesize that astrocyte and microglia activation may occur in parallel in the central nervous system.