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Papers of the Week
SFKs/p38 Pathway is Involved in Radicular Pain by Promoting Spinal Expression of Pro-Inflammatory Cytokines in a Rat Model of Lumbar Disc Herniation.
Abstract
MINI: Lumbar disc herniation always generates radicular pain and mechanism is not clear. In this study, we found spinal SFKs contributed to radicular pain by activating of p38 MAPK and increasing pro-inflammatory cytokines expression in rats with NP implantation. Targeting SFKs/p38 pathway may be helpful for alleviating radicular pain.