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Papers of the Week

Papers: 29 Jun 2019 - 5 Jul 2019

Animal Studies

2019 Jun 29

J Neuroinflammation



Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain.


Li Y-J, Zhang K, Sun T, Wang J, Guo Y-Y, Yang L, Yang Q, Li Y-J, Liu S-B, Zhao M-G, Wu Y-M
J Neuroinflammation. 2019 Jun 29; 16(1):132.
PMID: 31255170.


Liver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the brain. Here, the modes of action of LXRs and the epigenetic mechanisms regulating LXRβ expression in anterior cingulate cortex (ACC) of chronic inflammatory pain (CIP) are investigated.