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Papers of the Week

Papers: 29 Jun 2019 - 5 Jul 2019

Animal Studies, Pharmacology/Drug Development

2019 Aug

Br J Anaesth



Mitochondrial calcium uniporter contributes to morphine tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn.


Takahashi K, Yi H, Gu J, Ikegami D, Liu S, Iida T, Kashiwagi Y, Dong C, Kunisawa T, Hao S
Br J Anaesth. 2019 Aug; 123(2):e226-e238.
PMID: 31253357.


The long-term use of opioid analgesics is limited by the development of unwanted side-effects, such as tolerance. The molecular mechanisms of morphine anti-nociceptive tolerance are still unclear. The mitochondrial calcium uniporter (MCU) is involved in painful hyperalgesia, but the role of MCU in morphine tolerance has not been uncharacterised.