Low back pain (LBP) is yet the persistent public health challenges around the globe. It substantially affects quality of life and poses disability, particularly to the global working population. The profound losses in productivity and compensation premiums due to the condition have also been a challenge to contemporary occupational health. As such, it no doubt demands informed management and due response. The objective of this research was therefore to investigate the prevalence and work-related factors associated with low back pain among nurses in public hospitals in western Ethiopia.