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Papers of the Week

2019 Aug

Cancer Chemother Pharmacol



Oxaliplatin induces prostaglandin E2 release in vascular endothelial cells.


Matsunuma S, Handa S, Kamei D, Yamamoto H, Okuyama K, Kato Y
Cancer Chemother Pharmacol. 2019 Aug; 84(2):345-350.
PMID: 31243527.


Oxaliplatin (L-OHP) is known to induce adverse reactions at the injection site, including vascular pain, but the underlying mechanisms have not been clarified. Vascular pain during intravenous L-OHP administration can be inhibited by taking non-steroidal anti-inflammatory drugs (NSAIDs). In this study, we investigated the involvement of the arachidonic acid cascade and prostaglandin (PG) E and 15d-PGJ in vascular pain sensation during intravenous delivery of L-OHP.