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Papers of the Week

Papers: 22 Jun 2019 - 28 Jun 2019

Human Studies

2020 Feb 01

Pain Med



The Effect of Stress on Repeated Painful Stimuli with and Without Painful Conditioning.


Hoegh M, Poulsen JN, Petrini L, Graven-Nielsen T
Pain Med. 2020 Feb 01; 21(2):317-325.
PMID: 31241135.


Stress and pain have been interrelated in clinical widespread pain conditions. Studies indicate that acute experimental stress in healthy volunteers has a negative effect on the descending inhibitory pain control system and thus the ability to inhibit one painful stimulus with another (conditioned pain modulation [CPM]) although without effect on general pain sensitivity. CPM effects can be assessed immediately after the stress induction, whereas some physiological stress responses (e.g., cortisol release) are delayed and longer lasting. It is unclear whether CPM may relate to stress-induced increases in cortisol.