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Papers of the Week


2019 May


Iran J Basic Med Sci


22


5

Sumatriptan ameliorates renal injury induced by cisplatin in mice.

Authors

Bazmandegan G, Amirteimoury M, Kaeidi A, Shamsizadeh A, Khademalhosseini M, Nematollahi M H, Hassanipour M, Fatemi I
Iran J Basic Med Sci. 2019 May; 22(5):563-567.
PMID: 31217938.

Abstract

Cisplatin (Cis) is an anticancer compound, which is used for the treatment of various cancers. Sumatriptan (Suma) is a selective agonist of 5-hydroxytryptamine 1B/1D (5HT1B/1D) receptor, which is prescribed for the management of migraine. It is well-established that Suma has anti-inflammatory and antioxidant properties. We have explored the protective effects of Suma in the mitigation of Cis-induced nephrotoxicity.