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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Sex differences in the expression of calcitonin gene-related peptide receptor components in the spinal trigeminal nucleus.

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Papers: 22 Jun 2019 - 28 Jun 2019


Animal Studies


2019 Aug-Dec


Neurobiol Pain


http://www.ncbi.nlm.nih.gov/pubmed/31223141?dopt=Abstract


6

Sex differences in the expression of calcitonin gene-related peptide receptor components in the spinal trigeminal nucleus.

Authors

Sex differences in the expression of calcitonin gene-related peptide receptor components in the spinal trigeminal nucleus.
Ji Y, Rizk A, Voulalas P, Aljohani H, Akerman S, Dussor G, Keller A, Masri R
Neurobiol Pain. 2019 Aug-Dec; 6:100031.
PMID: 31223141.

Abstract

Calcitonin gene-related peptide (CGRP) plays an important role in migraine pathophysiology. CGRP acts primarily by activating a receptor composed of 3 proteins: calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and receptor component protein (RCP). We tested the hypothesis that sex differences exist in protein levels of two key components of this CGRP receptor: CLR and RCP.
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