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Papers of the Week

Papers: 15 Jun 2019 - 21 Jun 2019

Animal Studies, Pharmacology/Drug Development

2020 Feb

Anesth Analg



Methylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain.


You Z, Ding W, Doheny JT, Shen S, Yang J, Yang L, Chen L, Zhu S, Mao J
Anesth Analg. 2020 Feb; 130(2):518-524.
PMID: 31206430.


The incremental dose of opioids used in chronic pain management often leads to a reduced opioid analgesic effect, opioid misuse, and addiction. Central dopamine (DA) dysfunction contributes to the chronicity of pain and a decreased opioid analgesic effect. Methylphenidate (MPH/Ritalin) enhances central DA function by inhibiting DA reuptake. In this study, we used a rat model of chronic pain to examine whether combination of MPH with morphine (MOR) would improve the MOR analgesic effect under a chronic pain condition.