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Papers of the Week

Papers: 15 Jun 2019 - 21 Jun 2019

Human Studies

2019 Nov

J Oral Rehabil



Endogenous Pain Modulation Assessed with Offset Analgesia Is Not impaired in Chronic Temporomandibular Disorders Pain Patients.


Moana-Filho E J, Herrero Babiloni A, Nisley A
J Oral Rehabil. 2019 Nov; 46(11):1009-1022.
PMID: 31206773.


Abnormal endogenous pain modulation (EPM) was suggested as a pathophysiological characteristic of chronic pain. EPM has been investigated using psychophysical tests for pain facilitation and inhibition such as temporal summation of pain and conditioned pain modulation, respectively. Another psychophysical test for pain inhibition is offset analgesia (OA), where small variations in noxious stimulus intensity over time elicit a disproportionately large analgesic response. OA has been investigated in patients with mixed pain conditions, but not in chronic temporomandibular disorders (TMD) patients.