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Papers of the Week

Papers: 15 Jun 2019 - 21 Jun 2019

2019 Aug

Semin Fetal Neonatal Med



Nociception and the neonatal brain.


Gursul D, Hartley C, Slater R
Semin Fetal Neonatal Med. 2019 Aug; 24(4):101016.
PMID: 31201139.


Measuring brain activity in infants provides an objective surrogate approach with which to infer pain perception following noxious events. Here we discuss different approaches which can be used to measure noxious-evoked brain activity, and discuss how these measures can be used to assess the analgesic efficacy of pharmacological and non-pharmacological interventions. We review factors that can modulate noxious-evoked brain activity, which may impact infant pain experience, including gestational age, sex, prior pain, stress, and illness.