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Papers of the Week

2018 Jul



Efficacy and Safety of a Single Dose a Multiple Dose Regimen of Mebendazole against Hookworm Infections in Children: A Randomised, Double-blind Trial.


Single-dose mebendazole is widely used in preventive chemotherapy against the soil-transmitted helminths (STHs) , hookworm and , yet it shows limited efficacy against hookworm and infections. The use of adapted treatment regimens might provide a strategy to control and eliminate STH infections in STH-persistent settings. We evaluated the safety and efficacy of the multiple dose mebendazole regimen (3 days 100 mg bid) a single dose of 500 mg mebendazole in a setting with high STH prevalence and high drug pressure.