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The purpose of the study was to evaluate the possibility of using and the effectiveness of CO and diode lasers in the microsurgery of the vestibular larynx. 85 surgical interventions were performed (using CO laser – 45, diode – 40) on the vestibular larynx of 52 patients (papillomatosis, cicatricial stenosis, cysts, hyperplastic laryngitis, initial stage of laryngeal cancer). The complications, duration of the intervention and inflammatory changes after the operation were assessed. In 3 (3.5%) cases, the use of CO laser was complicated by bleeding. The duration of the intervention with the use of a CO laser averaged 24±5.6 minutes, with a diode laser 30±5.4 minutes (p<0.05). In patients with a diode laser, edema, mucosal congestion, fibrin and pain were significantly longer than patients after using a CO laser (p<0.05). Thus, the use of CO laser in the surgical treatment of the vestibular laryngeal region occurs with less time, a less prolonged inflammatory response, but in some cases requires additional methods of hemostasis.