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Papers of the Week

Papers: 15 Jun 2019 - 21 Jun 2019

Human Studies

2021 Apr




Observations of Autonomic Variability Following Central Neuromodulation for Chronic Neuropathic Pain in Spinal Cord Injury.


Karri J, Li S, Chen Y-T, Stampas A, Li S
Neuromodulation. 2021 Apr; 24(3):427-433.
PMID: 31199549.


Spinal cord injury (SCI) persons with chronic neuropathic pain (NP) demonstrate maladaptive autonomic profiles compared to SCI counterparts without NP (SCI - NP) or able-bodied (AB) controls. These aberrations may be secondary to maladaptive neuroplasticity in the shared circuitry of the pain neuromatrix-central autonomic network interface (PNM-CAN). In this study, we explored the proposed PNM-CAN mechanism in SCI + NP and AB cohorts following centrally-directed neuromodulation to assess if the PNM and CAN are capable of being differentially modulated.