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Papers of the Week

Papers: 8 Jun 2019 - 14 Jun 2019

Animal Studies

2019 Jun 11

J Neuroinflammation



BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury.


Sánchez-Ventura J, Amo-Aparicio J, Navarro X, Penas C
J Neuroinflammation. 2019 Jun 11; 16(1):124.
PMID: 31186006.


Spinal cord injury (SCI) usually causes a devastating lifelong disability for patients. After a traumatic lesion, disruption of the blood-spinal cord barrier induces the infiltration of macrophages into the lesion site and the activation of resident glial cells, which release cytokines and chemokines. These events result in a persistent inflammation, which has both detrimental and beneficial effects, but eventually limits functional recovery and contributes to the appearance of neuropathic pain. Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that regulate the expression of inflammatory genes by interacting with acetylated lysine residues. While BET inhibitors are a promising therapeutic strategy for cancer, little is known about their implication after SCI. Thus, the current study was aimed to investigate the anti-inflammatory role of BET inhibitors in this pathologic condition.