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Papers of the Week
A Dual Amylin and Calcitonin Receptor Agonist inhibits pain behavior and reduces cartilage pathology in an osteoarthritis rat model.
Abstract
Pain and disability are the main clinical manifestations of osteoarthritis, for which only symptomatic therapies are available. Hence, there is a need for therapies that can simultaneously alter disease progression and provide pain relief. KBP is a dual amylin- and calcitonin-receptor agonist with antiresorptive and chondroprotective properties. In this study we investigated the effect of KBP in a rat model of osteoarthritis.