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Papers of the Week

Papers: 8 Jun 2019 - 14 Jun 2019

Animal Studies, Pharmacology/Drug Development

2019 Sep

Osteoarthritis Cartilage



A Dual Amylin and Calcitonin Receptor Agonist inhibits pain behavior and reduces cartilage pathology in an osteoarthritis rat model.


Katri A, Dąbrowska A, Löfvall H, Karsdal MA, Andreassen KV, Thudium CS, Henriksen K
Osteoarthritis Cartilage. 2019 Sep; 27(9):1339-1346.
PMID: 31176015.


Pain and disability are the main clinical manifestations of osteoarthritis, for which only symptomatic therapies are available. Hence, there is a need for therapies that can simultaneously alter disease progression and provide pain relief. KBP is a dual amylin- and calcitonin-receptor agonist with antiresorptive and chondroprotective properties. In this study we investigated the effect of KBP in a rat model of osteoarthritis.