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Papers of the Week

Papers: 1 Jun 2019 - 7 Jun 2019

Human Studies, Pharmacology/Drug Development

2022 Nov

BMJ Support Palliat Care



Low-dose ketamine adjuvant treatment for refractory pain in children, adolescents and young adults with cancer: a pilot study.


Courade M, Bertrand A, Guerrini-Rousseau L, Pagnier A, Levy D, Lervat C, Cojean N, Ribrault A, Dugue S, Thouvenin S, Piguet C, Schmitt C, Marec-Berard P
BMJ Support Palliat Care. 2022 Nov; 12(e5):e656-e663.
PMID: 31151954.


Ketamine, an -methyl-D-aspartate receptor antagonist, is effective at relieving adult cancer pain, although there have been very few reports to date regarding its use in children and in adolescents and young adults (AYA). This study assessed the efficacy, safety and opioid-sparing effects of low doses of ketamine added to opioid analgesics to alleviate persistent cancer pain.