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Papers of the Week


Papers: 1 Jun 2019 - 7 Jun 2019


Human Studies, Pharmacology/Drug Development


2022 Nov


BMJ Support Palliat Care


12


e5

Low-dose ketamine adjuvant treatment for refractory pain in children, adolescents and young adults with cancer: a pilot study.

Authors

Courade M, Bertrand A, Guerrini-Rousseau L, Pagnier A, Levy D, Lervat C, Cojean N, Ribrault A, Dugue S, Thouvenin S, Piguet C, Schmitt C, Marec-Berard P
BMJ Support Palliat Care. 2022 Nov; 12(e5):e656-e663.
PMID: 31151954.

Abstract

Ketamine, an -methyl-D-aspartate receptor antagonist, is effective at relieving adult cancer pain, although there have been very few reports to date regarding its use in children and in adolescents and young adults (AYA). This study assessed the efficacy, safety and opioid-sparing effects of low doses of ketamine added to opioid analgesics to alleviate persistent cancer pain.