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Papers of the Week

Papers: 1 Jun 2019 - 7 Jun 2019


Animal Studies

2019 Jun 28



Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis.


Gadotti VM, Andonegui G, Zhang Z, M'Dahoma S, Baggio CH, Chen L, Basso L, Altier C, MacNaughton WK, Kubes P, Zamponi GW
iScience. 2019 Jun 28; 16:12-21.
PMID: 31146128.


Many patients with visceral inflammation develop pain and psychiatric comorbidities such as major depressive disorder, worsening the quality of life and increasing the risk of suicide. Here we show that neuroimmune activation in mice with dextran sodium sulfate-induced colitis is accompanied by the development of pain and depressive behaviors. Importantly, treatment with the flavonoid luteolin prevented both neuroimmune responses and behavioral abnormalities, suggesting a new potential therapeutic approach for patients with inflammatory bowel diseases.