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Papers of the Week


Papers: 25 May 2019 - 31 May 2019


Human Studies, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2019 Jul 01


JAMA Neurol


76


7

Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding.

Authors

Deen M, Hougaard A, Hansen H D, Schain M, Dyssegaard A, Knudsen G M, Ashina M
JAMA Neurol. 2019 Jul 01; 76(7):834-840.
PMID: 31135819.

Abstract

Triptans, the most efficient acute treatment for migraine attacks, are 5-HT1B/1D receptor agonists, but their precise mechanism of action is not completely understood. The extent to which triptans enter the central nervous system and bind to 5-HT1B receptors in the brain is unknown.