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Papers of the Week

Papers: 25 May 2019 - 31 May 2019

Pharmacology/Drug Development

2019 May 27

Cochrane Database Syst Rev


Tramadol for osteoarthritis.


Toupin April K, Bisaillon J, Welch V, Maxwell LJ, Jüni P, Rutjes A W, Husni EM, Vincent J, El Hindi T, Wells GA, Tugwell P
Cochrane Database Syst Rev. 2019 May 27; 5:CD005522.
PMID: 31132298.


Tramadol is often prescribed to treat pain and is associated physical disability in osteoarthritis (OA). Due to the pharmacologic mechanism of tramadol, it may lead to fewer associated adverse effects (i.e. gastrointestinal bleeding or renal problems) compared to non-steroidal anti-inflammatory drugs (NSAIDs). This is an update of a Cochrane Review originally published in 2006.