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Papers of the Week

Papers: 18 May 2019 - 24 May 2019

Animal Studies

2019 Aug

Neurogastroenterol Motil



Down-regulation of HTR1A-modulated ACC activation contributes to stress-induced visceral hyperalgesia in rats.


Yi L, Sun H, Zhang H, Chen Y, Zhou L, Xuan L, Zhan T, Jiang Y, Xu S
Neurogastroenterol Motil. 2019 Aug; 31(8):1-13.
PMID: 31121088.


Long-term stress was suggested to cause visceral hypersensitivity and promote functional gastrointestinal disorders (FGIDs). Some brain regions such as the anterior cingulate cortex (ACC) may play an important role for generating visceral hypersensitivity; however, its molecular mechanisms are not clear. This study aimed to explore the role of 5-HT1A receptors (HTR1As) in activating ACC and corresponding mechanism, in stress-induced visceral hyperalgesia rats.