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Papers of the Week

Papers: 18 May 2019 - 24 May 2019

Human Studies, Pharmacology/Drug Development

2019 Dec 01

Pain Med



Relief of Neuropathic Pain Through Epidermal Growth Factor Receptor Inhibition: A Randomized Proof-of-Concept Trial.


Kersten C, Cameron MG, Bailey AG, Fallon MT, Laird BJ, Paterson V, Mitchell R, Fleetwood-Walker SM, Daly F, Mjåland S
Pain Med. 2019 Dec 01; 20(12):2495-2505.
PMID: 31106835.


Case reports and a case series have described relief of neuropathic pain (NP) after treatment with epidermal growth factor receptor inhibitors (EGFR-Is). These observations are supported by preclinical findings. The aim of this trial was to explore a potential clinical signal supporting the therapeutic efficacy of EGFR-Is in NP.