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Papers of the Week

Papers: 18 May 2019 - 24 May 2019

2019 May 15

Clin Epigenetics



Functional roles of lncRNAs and its potential mechanisms in neuropathic pain.


Tang S, Zhou J, Jing H, Liao M, Lin S, Huang Z, Huang T, Zhong J, Zhong J
Clin Epigenetics. 2019 May 15; 11(1):78.
PMID: 31092294.


Neuropathic pain (NP) is ranked as one of the major forms of chronic pain and emerges as a direct consequence of a lesion or disease affecting the somatosensory nervous system. Despite great advances into the mechanisms of NP, clinical practice is still not satisfactory. Fortunately, progress in elucidating unique features and multiple molecular mechanisms of long non-coding RNAs (lncRNAs) in NP has emerged in the past 10 years, suggesting that novel therapeutic strategies for pain treatment may be proposed. In this review, we will concentrate on recent studies associated with lncRNAs in NP. First, we will describe the alterations of lncRNA expression after spinal cord injury (SCI) and peripheral nerve injury (PNI), and then we illustrate the role of some specific lncRNAs in detail, which may offer new insights into our understanding of the etiology and pathophysiology of NP. Finally, we put special emphasis on the altered expression of lncRNAs in the diverse biological process of NP. Recent advances we summarized above in the development of NP may facilitate translation of these findings from bench to bedside in the future.