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Papers of the Week

2019 Jun

Eur J Contracept Reprod Health Care



Effect of desogestrel 75 µg on headache frequency and intensity in women with migraine: a prospective controlled trial.


Merki-Feld GS, Imthurn B, Gantenbein AR, Sandor P
Eur J Contracept Reprod Health Care. 2019 Jun; 24(3):175-181.
PMID: 31094588.


In contrast with combined hormonal contraception, progestin-only contraception is not associated with an increase in venous thromboembolism or stroke. Women with migraine are at increased risk of ischaemic stroke. Several studies have reported a reduction in migraine frequency and intensity with desogestrel 75 µg, a progestin-only pill. At present the quality of data is limited by retrospective study designs, lack of control groups and small sample sizes. We present the first prospective nonrandomised controlled trial.