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Diagn Progn Res


Prognosis research ideally should measure time-varying predictors at their intended moment of use.


Whittle R, Royle K-L, Jordan KP, Riley RD, Mallen CD, Peat G
Diagn Progn Res. 2017; 1:1.
PMID: 31093533.


Prognosis research studies (e.g. those deriving prognostic models or examining potential predictors of outcome) often collect information on time-varying predictors their intended moment of use, sometimes using a measurement method different to that which would be used. We aimed to illustrate how estimates of predictor-outcome associations and prognostic model performance obtained from such studies may differ to those at the earlier, intended moment of use.