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Papers of the Week

Papers: 18 May 2019 - 24 May 2019

Animal Studies, Pharmacology/Drug Development

2019 Sep

Psychopharmacology (Berl)



The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats.


Hiranita T, Leon F, Felix JS, Restrepo LF, Reeves ME, Pennington AE, Obeng S, Avery BA, McCurdy CR, McMahon LR, Wilkerson JL
Psychopharmacology (Berl). 2019 Sep; 236(9):2725-2734.
PMID: 31098655.


Mitragyna speciosa (kratom) may hold promise as both an analgesic and treatment for opioid use disorder. Mitragynine, its primary alkaloid constituent, is an opioid receptor ligand. However, the extent to which the in vivo effects of mitragynine are mediated by opioid receptors, or whether mitragynine interacts with other opioid agonists, is not fully established.