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Papers of the Week

Papers: 4 May 2019 - 10 May 2019

Human Studies, Pharmacology/Drug Development

2019 Jul 01

Drug Alcohol Depend


Sensitized brain response to acute pain in patients using prescription opiates for chronic pain: A pilot study.


Dowdle LT, Borckardt JJ, Back SE, Morgan K, Adams D, Madan A, Balliet W, Hanlon CA
Drug Alcohol Depend. 2019 Jul 01; 200:6-13.
PMID: 31071496.


Chronic opiate use leads to a sensitized behavioral response to acute pain, which in turn, leads to escalating doses of opiates. This study was designed to test the hypothesis that chronic opiate usage is also associated with a sensitized neurobiological response to acute pain in individuals that have used prescription opiates for 6 or more months.