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Papers of the Week

2019 Aug

World Neurosurg


A rare high-grade glioma with a histone H3 K27M mutation in the hypothalamus of an adult patient: a case report.


He P, Chen W, Qiu X, Xi Y B, Guan H, Xia J
World Neurosurg. 2019 Aug; 128:527-531.
PMID: 31048046.


"Diffuse midline glioma, H3 K27M-mutant" is a new tumor entity described in the revised 2016 World Health Organization classification. It is most frequently observed in children, and develops in midline structures including the brainstem, thalamus, and spine. We describe a rare diffuse midline glioma with an H3 K27M mutation arising in the hypothalamus of an adult.