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Papers of the Week

Papers: 27 Apr 2019 - 3 May 2019

Animal Studies

2019 Aug

Br J Anaesth



Neurosteroid dehydroepiandrosterone sulphate enhances pain transmission in rat spinal dorsal horn.


Yamamoto G, Kamiya Y, Sasaki M, Ikoma M, Baba H, Kohno T
Br J Anaesth. 2019 Aug; 123(2):e215-e225.
PMID: 31030988.


The neurosteroid dehydroepiandrosterone sulphate (DHEAS) activates the sigma-1 receptor, inhibits gamma-aminobutyric acid A (GABA) and glycine receptors, and induces hyperalgesic effects. Although its effects have been studied in various tissues of the nervous system, its synaptic mechanisms in nociceptive pathways remain to be elucidated.