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Papers of the Week
Neurosteroid dehydroepiandrosterone sulphate enhances pain transmission in rat spinal dorsal horn.
Abstract
The neurosteroid dehydroepiandrosterone sulphate (DHEAS) activates the sigma-1 receptor, inhibits gamma-aminobutyric acid A (GABA) and glycine receptors, and induces hyperalgesic effects. Although its effects have been studied in various tissues of the nervous system, its synaptic mechanisms in nociceptive pathways remain to be elucidated.