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Papers of the Week

2019 Aug

Br J Clin Pharmacol



Analgesic efficacy and pharmacokinetics of epidural oxycodone in pain management after gynaecologic laparoscopy – a randomised, double blind, active control, double-dummy clinical comparison with intravenous administration.


Early pain after laparoscopy is often severe. Oxycodone is a feasible analgesic option after laparoscopy, but there are sparse data on epidural administration. The aim was to evaluate the analgesic efficacy and pharmacokinetics of a single dose of epidural oxycodone as a part of multimodal analgesia after gynaecologic laparoscopy.