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Papers of the Week

Papers: 20 Apr 2019 - 26 Apr 2019

Human Studies

2019 Apr 05

JAMA Netw Open



Association Between Opioid Dose Variability and Opioid Overdose Among Adults Prescribed Long-term Opioid Therapy.


Glanz JM, Binswanger IA, Shetterly SM, Narwaney KJ, Xu S
JAMA Netw Open. 2019 Apr 05; 2(4):e192613.
PMID: 31002325.


Attempts to discontinue opioid therapy to reduce the risk of overdose and adhere to prescribing guidelines may lead patients to be exposed to variability in opioid dosing. Such dose variability may increase the risk of opioid overdose even if therapy discontinuation is associated with a reduction in risk.