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Papers of the Week

Papers: 20 Apr 2019 - 26 Apr 2019

Animal Studies

2019 Apr 24

BMC Neurosci



Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain.


Sosanya NM, Garza TH, Stacey W, Crimmins SL, Christy RJ, Cheppudira BP
BMC Neurosci. 2019 Apr 24; 20(1):17.
PMID: 31014242.


Reports show that stressful events before injury exacerbates post-injury pain. The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we examined the effects of chronic intermittent stress (CIS) on nociceptive behaviors and brain-derived nerve growth factor (BDNF) system in the prefrontal cortex (PFC) and hypothalamus of rats with and without thermal injury.