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Papers of the Week

Papers: 20 Apr 2019 - 26 Apr 2019

Human Studies

2019 06

Musculoskelet Sci Pract


Development of a topical menthol stimulus to evaluate cold hyperalgesia.


Wright A, Benson HAE, Moss P
Musculoskelet Sci Pract. 2019 06; 41:55-63.
PMID: 31010570.


Cold hyperalgesia is an indicator of widespread pain sensitivity and is associated with poor clinical outcomes. Menthol activates TRPM8, a cold-sensing receptor channel. This research evaluated topical menthol as a potential stimulus to be used in the clinical evaluation of cold hyperalgesia.