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Papers of the Week

Papers: 20 Apr 2019 - 26 Apr 2019

Animal Studies

2019 Jan-Dec

Mol Pain


X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation.


Su C, Xu J, Liu X, Zhao F, Pan J, Shi A, Hu D, Yu Y, Liu T, Zhang Y
Mol Pain. 2019 Jan-Dec; 15:1744806919849201.
PMID: 31012378.


Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation (IR)-induced pain are largely unknown. In present study, mice were treated with 20 Gy X-ray to establish IR-induced pain model. X-ray evoked a prolonged mechanical, heat and cold allodynia in mice. Transient receptor potential vanilloid 1 (TRPV1) and transient receptor potential ankyrin 1 (TRPA1) were significantly upregulated in lumbar dorsal root ganglion (DRG). The mechanical and heat allodynia could be transiently reverted by intrathecal injection of TRPV1 antagonist capsazepine and TRPA1 antagonist HC-030031. Additionally, the phosphorylated ERK and JNK in pain neural pathway were induced by X-ray treatment. Our findings indicated activation of TRPA1 and TRPV1 is essential for the development of X-ray-induced allodynia. Furthermore, our findings suggest targeting on TRPV1 and TRPA1 may be promising prevention strategies for X-ray-induced allodynia in clinical practice.