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Papers of the Week

Papers: 20 Apr 2019 - 26 Apr 2019

Human Studies

2019 Aug

Osteoarthritis Cartilage



Inflammatory cytokines mediate the effects of diet and exercise on pain and function in knee osteoarthritis independent of BMI.


Runhaar J, Beavers DP, Miller GD, Nicklas B, Loeser R, Bierma-Zeinstra S, Messier S
Osteoarthritis Cartilage. 2019 Aug; 27(8):1118-1123.
PMID: 31009749.


Diet restriction and exercise form key treatments for osteoarthritis (OA) related symptoms in overweight and obese individuals. Although both interventions are known to influence systemic low-grade inflammation, which is related to pain levels and functional limitations, little is known about the potential changes in systemic inflammation as a working mechanism of diet restriction and exercise in knee OA.